Diagnostic value of GenoType? MTBDRsl assay for the resistance to fluoroquinolones anti-tuberculosis drugs:a Meta-analysis
10.3969/j.issn.1673-4130.2015.21.017
- VernacularTitle:GenoType棆MTBDRsl试验检测喹诺酮类抗结核药耐药性准确性的Meta分析
- Author:
Zhe CUI
;
Fei WEN
;
Lu HAN
- Publication Type:Journal Article
- Keywords:
GenoType? MTBDRsl assay;
fluoroquinolones;
resistance;
diagnostic test;
Meta-analysis;
tuberculosis
- From:
International Journal of Laboratory Medicine
2015;(21):3119-3122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic accuracy of GenoType? M TBDRsl for the resistance to fluoroquinolones anti‐tuberculosis drugs .Methods Systematic and comprehensive literature was searched in PubMed ,Embase ,Web of Science ,CBM , CNKI ,VIP and Wanfang database .The relative studies of GenoType? MTBDRsl to fluoroquinolones anti‐tuberculosis drugs were included .After quality assessment ,Meta‐Disc1 .4 software was used to analyze the data .Results A total of 16 trials ,involving 1 766 participants ,were included .The results of Meta‐analysis showed that the weighted sensitivity ,specificity ,positive likelihood ra‐tio ,negative likelihood ratio ,diagnostic odds ratio ,and the area under summary receiver operation curve were 0 .83 ,0 .96 ,17 .50 , 0 .20 ,108 .46 and 0 .934 9 ,respectively .Conclusion GenoType? M TBDRsl assay for the resistance to fluoroquinolones anti‐tuber‐culosis drugs might be with high sensitivity and specificity ,which could be recommended as efficacy diagnostic tool .
