Effect of Omeprazole Combined with Glutamine in the Prevention of Stress Ulcer
- VernacularTitle:奥美拉唑联合谷氨酰胺预防应激性溃疡效果观察
- Author:
Zhan ZHAO
;
Buwu LI
;
Huanle YE
;
Huawei ZHAI
- Publication Type:Journal Article
- Keywords:
Omeprazole;
Glutamine;
Stress ulcer;
Efficacy
- From:
China Pharmacist
2015;18(10):1750-1752
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of omeprazole combined with glutamine in the prevention of stress ulcer. Methods:To-tally 106 cases of severe patients admitted in ICU of our hospital were divided into the observation group and the control group with 53 ones in each according to the admission order. The patients in the control group were treated with glutamine, and those in the observa-tion group were treated with sodium omeprazole combined with glutamine. The pH change in gastric juice, adverse reactions and inci-dence of stress ulcer after the treatment were observed and compared between the two groups. Results:After the 4-day treatment, the pH value of gastric juice in the observation group was significantly higher than that in the control group (P<0. 05), and after the 7-day treatment, the difference was more notable. After the treatment, the symptoms of upper digestive tract in the observation group were fewer than those in the control group (P<0. 05). After the treatment, the observation group had three stress ulcer patients with the incidence rate of 5. 66%, while that in the control group was higher (24. 53%), and the difference was statistically significant (P<0. 05). There was no statistically significant difference in the adverse reactions between the two groups (P>0. 05). Conclusion:Omeprazole combined with glutamine in the prevention of ulcers stress shows promising clinical efficacy, which can effectively inhibit gastric acid secretion and rapidly increase pH value of gastric juice with low incidence of adverse reactions, mild symptoms and high se-curity, and is worthy of wide use in clinics.
