Intracoronary Ergonovine Provocation Test in Patients with Coronary Artery Spasm.
10.4070/kcj.1994.24.1.53
- Author:
Kyoo Rok HAN
;
Dong Ju CHOI
;
Young Jin CHOI
;
Sun Soo PARK
;
Yong Jin KIM
;
Dae Won SOHN
;
Byung Hee OH
;
Myoung Mook LEE
;
Young Bae PARK
;
Yun Shik CHOI
;
Jung Don SEO
;
Young Woo LEE
- Publication Type:Original Article
- Keywords:
Intracoronary;
Ergonovine;
Provocation test;
Coronary artery spasm
- MeSH:
Acetylcholine;
Chest Pain;
Coronary Angiography;
Coronary Vessels*;
Depression;
Electrocardiography;
Ergonovine*;
Female;
Humans;
Phenobarbital;
Spasm*
- From:Korean Circulation Journal
1994;24(1):53-59
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Intravenous ergonovine and intracoronary acetylcholine tests have been used to induce coronary artery spasm, however, potential preblems with each test require a safer and more specific test. METHODS: To evaluate the usefulness of the intracoronary ergonovine provocation test in patients with coronary artery spasm, this test was performed in 83 patients(male 47, female 36) with normal or near-normal looking coronary angiography or insignificant lesion less than 50% in diameter after routine diagnostic coronary angiography. Ten micrograms of ergonovine maleate diluted in 1 ml of saline was injected into right coronary artery up to 2 times and into left coronary artery up to 3 times. Induction of coronary arterial narrowing more than 75% of luminal diameter with typical chest pain and/or ECG changes in two or more adjacent leads was considered as a positive test. RESULTS: Intracoronary ergonovine provocation tests were positive in 33 patients among 83 patients. In 24 patients, coronary artery spasm was induced in RCA, 12 patients in LAD and 8 patients in LCX. Coronary artery spasm of 2 sites was observed in 11 patients. In 27 patients, typical chest pain was developed with spasm. The ECG changes during spasm were ST elevation in 19 patients, ST depression in 3 patients, T wave change only in 2 patients and no change in 9 patients. The provocation tests showed focal spasm in 23 patients(70%) and diffuse spasm in 10 patients(30%). CONCLUSION: Intracoronary ergonovine provocation test appears to be a safe and effective method to provoke the coronary artery spasm.
