Optimization of Extraction Technology of Compound Xiongdan Capsules by Orthogonal Test
- VernacularTitle:正交试验法优化复方熊胆胶囊药材提取工艺
- Author:
Xiaole XU
;
Qiong DU
;
Bo YU
;
Qing ZHAI
- Publication Type:Journal Article
- Keywords:
Compound Xiongdan capsules;
Orthogonal design;
Water technology;
Ginsenoside
- From:
China Pharmacist
2015;18(10):1796-1798
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the extraction technology of compound Xiongdan capsules. Methods: The effects of water a-mount, decoction duration and decoction times on the water extraction technology were investigated by orthogonal design using the ex-tract derivation rate and the content of ginsenoside Rg1 , Re and Rb1 as the indices. Results:The optimal water extraction conditions for ginseng and Nidus vespa were as follows:decocting three times with 8-fold of water, and extracting for one hour each time. The extract was condensed until the relative density was 1.20(80-90℃), and then dried and crushed into fine powder. The other herbs were crushed into fine powder and screened by No. 5 meshes. The above powder was blended and well mixed with starch, and then packed into capsules. Conclusion:The optimized water extraction technology is stable, feasible and reproducible, which provide reference for industrial production.
