Anti-inflammatory, Analgesia and Antipyretic Effects of Chaige Qingre Granules
- VernacularTitle:柴葛清热颗粒抗炎镇痛解热作用研究
- Author:
Junfen ZENG
;
Jinchun SONG
;
Jianwu LU
- Publication Type:Journal Article
- Keywords:
Chaige Qingre granules;
Anti-inflammation;
Analgesia;
Relieving fever
- From:
China Pharmacist
2015;(8):1407-1409
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the anti-inflammatory, analgesia and antipyretic effects of Chaige Qingre granules. Meth-ods:Kunming mice were used to make auricle swelling model by dimthylphenanthrene, and the auricle swelling degree was measured to test the anti-inflammatory effect of Chaige Qingre granules. Mice were used to make pain models by acetic acid, and the body twis-ting of the mice was counted to observe the analgesia effect of the granules. The fever model in rats was induced by yeast, and the body temperature of the rats was measured to investigate the antipyretic effects of the granules. Results:Chaige Qingre granules could relieve the auricle swelling degree significantly, and the inhibition rate was 46. 3% in the high dose group. High and middle dose groups could reduce the body twisting frequency with the inhibition rate of 51. 1% and 61. 8%, respectively. Every Chaige Qingre granules group could lower the body temperature after one hour of the administration, and the temperature could be reduced 0. 56 degrees Celsius in the high dose group. Conclusion:Chaige Qingre granules can effectively inhibit auricle swelling degree, relieve pain and reduce heat.
