The short term effects of five second-generation antipsychotics on serum prolactin in the first-episode schizophrenia patients
10.3969/j.issn.1002-0152.2015.07.002
- VernacularTitle:五种常用二代抗精神病药物对首发精神分裂症患者泌乳素的近期影响
- Author:
Houliang WANG
;
Jingpin ZHAO
;
Hongying HAN
;
Shenglin WEN
;
Juncheng ZHANG
- Publication Type:Journal Article
- Keywords:
Risperidone;
Olanzapine;
Quetiapine;
Paliperidone;
Ziprasidone;
Prolactin (PRL)
- From:
Chinese Journal of Nervous and Mental Diseases
2015;(7):389-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the short term effects of five second-generation antipsychotics on the serum pro?lactin levels of first-episode schizophrenia patients. Methods Two hundred fifty first-episode schizophrenia patients were randomly divided into five groups and were then treated with risperidone, olanzapine, paliperidone, quetiapine or ziprasidone, respectively. The serum prolactin were tested at baseline, and every week following initiation of treatment. The positive and negative symptom scale (PANSS) and the treatment emergent symptom scale (TESS) were used to evalu?ate the effect and side effect of treatment. Results Repeated measure ANOVA for serum prolactin showed that the main effects of time, the main effect of group, and the interactive effect of time and group were significant (all P<0.01). At the first week, the serum prolactin level of risperidone group was higher than all the other four groups (P<0.05). At the sec?ond, third, fourth and fifth week, the serum prolactin level of risperidone group and olanzapine group was higher than the other three groups (P<0.05). At the end of the sixth week, the serum prolactin level of risperidone group, olanzapine group and paliperidone group was higher than the quetiapine and ziprasidone groups (P<0.05). But serum prolactin level of risperidone group and olanzapine group was higher than that of paliperidone group (P<0.05). The changes of PANSS before and after treatment were significantly different among groups (P<0.05). However, the incidence of the side effects was not significantly different among groups (P>0.05). Conclusion The level of serum prolactin gradually increases in schizophrenia patients receiving treatment of antipsychotics. The short term effects of different second generation antipsy?chotics on serum prolactin vary differently. Risperidol and olanzapine result in the elevation of serum prolactin level in the early period of treatment.
