Clinical Efficacy of Gabapentin Capsules in the Treatment of PHN Patients with Anxiety
- VernacularTitle:加巴喷丁联合用药治疗带状疱疹后神经痛伴焦虑患者的疗效观察
- Author:
Chuanguang WANG
;
Lipei LEI
;
Wei WU
;
Min ZHANG
;
Weidong FU
- Publication Type:Journal Article
- Keywords:
Gabapentin capsules( GBP);
Amitriptyline;
Tramadol;
Postherpetic neuralgia( PHü);
Anxiety
- From:
China Pharmacist
2015;(4):592-594
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of gabapentin capsules( GBP)combined with amitriptyline and tramadol in the treatment of patients with postherpetic neuralgia( PHü)and anxiety. Methods:Totally 106 PHü patients with anxiety symptoms at different degree were selected and divided into group A(n=53)and group B(n=53). Group A was given GBP,amitriptyline and tramadol,while group was given GBP only. The anxiety,depression,quality of life and pain-relieving intensity( by VAS)of the pa-tients were determined before the medication( T1 )and in the first week( T2 )and the fourth week( T3 )after the medication. Follow-up was carried out regularly according to the requirements to evaluate the clinical efficacy. Results:The anxiety,depression and VAS scores in the two groups on T2 were statistically significant lower than the corresponding results on T1(P<0.05). On T3,however, there were statistically significant differences between the two groups(P<0. 05). The total adverse reaction rate of group A was signif-icantly lower than that of group B(P<0. 05). The total effective rate of group A was significantly higher than that of group B(P<0. 05). Conclusion:GBP combined with tramadol and amitriptyline in the treatment of PHü patients with anxiety can effectively con-trol the pain of the patients,significantly reduce the scores of VAS and improve the quality of life of the patients.
