Expression of HMGB1 in glioma tissue of glioma-related epilepsy and epileptic seizures
10.3936/j.issn.1002-0152.2015.03.006
- VernacularTitle:胶质瘤相关性癫痫瘤组织中高迁移率族蛋白B1表达与痫性发作
- Author:
Xinjun WANG
;
Ruyi YANG
;
Qiao SHAN
;
Peidong LI
;
Jianheng WU
;
Yuehui WU
- Publication Type:Journal Article
- Keywords:
HMGB1;
Glioma tissue;
Glioma-related epilepsy
- From:
Chinese Journal of Nervous and Mental Diseases
2015;(3):155-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore expression of HMGB1 in glioma tissue of glioma-related epilepsy patients. Methods Immunohistochemistry was used to detect the expression of HMGB1 in the tissues from 82 glioma-related epi?lepsy patients (glioma-related epilepsy group), 80 glioma patients (glioma without epilepsy group), 80 intractable epilepsy patients (epilepsy control group) epileptogenic foci tissue and 20 normal controls (negative control group). Results HMGB1 in glioma tissue of glioma-related epilepsy group was significantly higher than that in glioma tissue of glioma without epilepsy grou p (χ2=16.944, P<0.001), especially in low pathological grade glioma tissue. HMGB1 was higher in glioma tissue of glioma-related epilepsy group than in epileptogenic foci tissue of epilepsy control group (χ2=26.094, P<0.001). Expression of HMGB1 in glioma tissue of glioma without epilepsy group (χ2=32.273, P<0.001) and epileptogenic foci tissue of epilepsy control group ( χ2=22.236,P<0.001) was higher than in normal brain tissue of negative control group. In glioma-related epilepsy group, HMGB1 was positively correlated with seizures duration(r=0.365,P=0.001), sei? zures frequency (r=0.531,P=0.000) and pathological grade of glioma tissue (r=0.265,P=0.016). Conclusions HMGB1 is highly expressed in glioma tissues of glioma-related epilepsy; HMGB1 expression is closely related with seizures; and HMGB1 in glioma tissue may contribute to the formation of glioma-related epilepsy.
