Effect of intensive blood pressure reduction on peri-hematomal secondary neuronal injury and prognosis in patients with intracerebral hemorrhage
10.3936/j.issn.1002-0152.2015.03.001
- VernacularTitle:积极降压对脑出血血肿周围继发神经元损伤及预后的影响
- Author:
Hong ZHANG
;
Jie YANG
;
Xindao YIN
;
Qingqing XU
;
Junshan ZHOU
- Publication Type:Journal Article
- Keywords:
Intracerebral hemorrhage;
Blood pressure;
Prognosis;
Magnetic resonance spectroscopy
- From:
Chinese Journal of Nervous and Mental Diseases
2015;(3):129-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of early intensive blood pressure (BP) lowering treatment on peri-he?matomal secondary neuronal injury and prognosis after acute intracerebral hemorrhage. Methods A randomised con?trolled trial consisting of 36 consecutive patients within 6 h of intracerebral hemorrhage onset were randomly assigned to intensive BP lowering group and guideline BP lowering group. All patients underwent MR spectroscopy at 72 h and were followed up 90 days. N Acetyl Aspartate/Creatine (NAA/Cr) and lactic acid wave around peri-hematomal at 72 h, neuro?logic function at early stage, and death and/or disability at 90d were compared between these two group. Results Spec?trum lines were obtained from thirty-one patients:14 from intensive BP lowing group and 17 from guideline BP lowering group. There was no significant difference in the percentage declines of NAA/Cr at 72 h between the two groups (13.3%± 4.2% vs. 11.9%± 2.8%, P = 0.308). There was no statistical differences either in neurologic function at 7 d or in death and/or disability at 90 d (P>0.05). Conclusions Early intensive BP-lowering treatment had no role on peri-hematomal secondary neuronal injury and prognosis after acute intracerebral hemorrhage. Further high-quality and large-scale ran?domised controlled trial are necessary to verify this result.
