An open label study of the effects of oral prednisone on neuromyelitis optica
10.3936/j.issn.1002-0152.2015.03.004
- VernacularTitle:维持性泼尼松治疗视神经脊髓炎的疗效观察
- Author:
Xuan WU
;
Aiyu LIN
;
Huayan WANG
;
Huixing WEI
;
Danni WANG
;
Ning WANG
- Publication Type:Journal Article
- Keywords:
Neuromyelitis optica;
Prednisone;
Therapy
- From:
Chinese Journal of Nervous and Mental Diseases
2015;(3):145-149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of oral prednisone in patients with relapsing neuromyeli?tis optica. Methods Seventeen patients with relapsing neuromyelitis optica receiving long-term oral prednisone had been followed. The Expanded Disability Status Scale (EDSS) and annualized relapse rates were used to evaluate curative effect. Results During long-term oral prednisone treatment, patients had a significant reduction in the EDSS [(3.09 ± 0.85) vs. (4.06 ± 0.80), P<0.05] and the median annualized relapse rate was significant reduced [(0.34 ± 0.31) vs. (1.51 ± 0.57), P<0.005]. But the effect of different dosage of prednisone on annualized relapse rates was not different. No severe adverse re?actions were observed. Conclusions Treatment with long-term oral prednisone in patients with NMO significantly reduces relapse rates, improves neurological function and the treatment was well-tolerated.
