The impact of childhood maltreatment experience and MAOA-VNTR on female adolescent’s impulsivity trait

VernacularTitle:单胺氧化酶A基因串联重复序列与童年期虐待对女性青少年冲动特质的影响
Author: Yun ZHANG ; Qingsen MING ; Lirong MA ; Xinru LI ; Yanfen WANG
Publication Type:Journal Article
Keywords: Childhood abuse; Gene-environment interaction; Impulsivity; MAOA-VNTR
From: Chinese Journal of Nervous and Mental Diseases 2015;(5):281-287
CountryChina
Language:Chinese
Abstract: Objective To examine the impact on impulsivity trait by monoamine oxidase A variable nucleotide tan?dem repeat (MAOA-VNTR) genotype and children’s abuse experience. Methods The self-reported questionnaire of Bar?ratt Impulsiveness Scale (BIS), Childhood Trauma Questionnaire (CTQ) were conducted in 403 normal Han female adoles?cents from north-west of China. The DNA were extracted from their venous blood sample and were genotyped for the MAOA-VNTR polymorphism. A linear regression model was used to investigate the main effects of MAOA-VNTR and children's abuse, and their interaction effect on impulsivity. Results The main effect of Children’s maltreatment experi?ence on trait impulsivity was significant (P<0.01). The main effect of MAOA-VNTR gene and the interaction between MAOA-VNTR genotype and children's maltreatment experience were insignificant (P>0.05). Conclusion The MAOA-VNTR genotype may not be involved in the female adolescents’impulsivity traits related to childhood maltreat?ment.