The effect of low frequency repetitive transcranial magnetic stimulation combined with duloxetine in treat-ment of depression
10.3936/j.issn.1002-0152.2015.05.007
- VernacularTitle:低频重复经颅磁刺激联合度洛西汀治疗抑郁障碍
- Author:
Jun ZHANG
;
Ming CUI
;
Yanhai WU
;
Hongmei SONG
;
Changping ZHAI
;
Jiapei DENG
;
Shouhu WANG
;
Xiangfen LUO
;
Sheng WANG
- Publication Type:Journal Article
- Keywords:
Repetitive transcranial magnetic stimulation;
Duloxetine;
Depression
- From:
Chinese Journal of Nervous and Mental Diseases
2015;(5):288-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and safety of repetitive transcranial magnetic stimulation combined with duloxetine in treatment of depression. Methods Sixty-nine cases of depression were randomly divided in?to study group (n=35 patients) and control group (n=34 patients). The study group received duloxetine combined with 1Hz rTMS treatment on the right dorsolateral prefrontal cortex area for 6 weeks whereas the control group received duloxetine combined with pseudo-rTMS treatment for 6 weeks. The Hamilton Depression Rating Scale (HAMD-24) and Treatment Emergent Symptom Scale (TESS) were used to assess the clinical efficacy and the adverse reactions before, 2, 4 and 6 weeks after the treatment, respectively. Results Four patients (two from each group) dropped out of the study. The main effects of time (P<0.001) and groups (P=0.029) were significant and so was the interactive effect of time and group (P<0.001). The clinical curative effect of the study group were significantly better compared with the control group at the 2, 4, 6 weeks following treatment (P<0.001). The adverse reactions were mild in these two groups. Conclusions The combi?nation of 1 Hz rTMS with duloxetine is superior to either medication alone for the treatment depression.
