Determination of Amantadine Hydrochloride in Pediatric Paracetamol and Amanatadine Hydrochloride Granules by GC
- VernacularTitle:气相色谱法测定小儿氨酚烷胺颗粒中盐酸金刚烷胺的含量
- Author:
Jing QIU
;
Da TONG
;
Xiaoyan LI
- Publication Type:Journal Article
- Keywords:
GC;
Pediatric paracetamol and amanatadine hydrochloride granules;
Amantadine hydrochloride;
Content determina-tion
- From:
China Pharmacist
2015;(6):1067-1069
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a GC method for determining the content of amantadine hydrochloride in pediatric paracetamol and amanatadine hydrochloride granules. Methods:The ingredients were separated on an Agilent DB-5 quartz capillary column (30 m ×0.25 mm, 0.25 μm), the carrier gas was N2,and the flow rate was 1 ml·min-1. The column temperature was maintained at 130℃, the injection temperature was 250℃,the detection temperature was 280℃ with an FID as the detector , the injection volume was 2 μl, and the split ratio was 20∶1. Results:A good linear relationship was obtained between the peak area and the concentration of amantadine hydrochloride within the range from 0.103 2 to 6.456 0 mg·ml-1(r =0.999 9). The average recovery was 100.18%(RSD=0. 11%, n=6). Conclusion:The method is specific, accurate, reliable and reproducible, which can be used in the quality control of pediatric paracetamol and amanatadine hydrochloride granules.
