Effect of Hydroxypropyl Starch Vacant Capsules on the Content of Spironolactone
- VernacularTitle:羟丙基淀粉空心胶囊对螺内酯含量的影响
- Author:
Fangwen SHUAI
;
Jiawei ZHANG
;
Xiangfeng WANG
;
Mi SONG
;
Honghao ZHOU
- Publication Type:Journal Article
- Keywords:
Vacant capsules made from hydroxypropyl starch;
Spironolactone;
Gelatin capsules;
Content determination
- From:
China Pharmacist
2015;(6):1052-1054
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of vacant capsules made from hydroxypropyl starch on the content of spironolac-tone. Methods:The spironolactone capsules were placed under the conditions with (4 000 ± 500) lx, 40℃ and RH (75 ± 5) % for 5 days and 10 days, respectively. An HPLC method was used to analyze the content of spironolactone, and the changes in appearance, color and the other traits were also observed. Results:The content of spironolactone was within the range of 93. 45%-100. 37% after the above tests, which was conformed to the standard(93. 0%-107. 0%). Conclusion:The vacant capsules made from hydroxypropyl starch rival have good compatibility with spironolactone.
