Clinical Observation of Bailing Capsules Combined with Calcium Dobesilate Dispersible Tablets in the Treatment of Diabetic Nephropathy in Phase Ⅳ
- VernacularTitle:羟苯磺酸钙分散片联合百令胶囊治疗糖尿病肾病Ⅳ期临床观察
- Author:
Ping WANG
;
Huizhi GAO
;
Shiwen WAN
;
Yanmei XUE
- Publication Type:Journal Article
- Keywords:
Calcium dobesilate dispersible tablets;
Bailing capsules;
Diabetic nephropathy in phase Ⅳ
- From:
China Pharmacist
2015;(6):967-969
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the therapeutic effect on blood glucose, lipid, and renal function of Bailing capsules combined with calcium dobesilate dispersible tablets in the treatment of diabetic nephropathy. Methods: Totally 216 patients with diabetic ne-phropathy in phase Ⅳ were randomly divided into the control group (108 cases) and the treatment group (108 cases). The control group was given the conventional therapy, and the treatment group was treated with Bailing capsules combined with calcium dobesilate dispersible tablets additionally. The levels of serum creatine (Scr), urean ntrogen (BUN), endothelin (ET-1), β2-microglobulin (β2-MG) ,cystatin C ( CYC) and urinary albumin excretion rate ( UAER) were detected for all the patients before and after the treat-ment. The adverse drug reactions were observed as well. Results:After the treatment, all the indices in the two groups were all obvi-ously decreased (P<0. 05), and those in the treatment group were significantly lower than those in the control group (P<0. 05). There were no significant changes in blood glucose, blood lipid and glycosylated hemoglobin before and after the treatment in the two groups (P>0. 05). The adverse drug reactions showed no significant differences between the two groups (P>0. 05). Conclusion:The effect of Bailing capsules combined with calcium dobesilate dispersible tablets is better than that of calcium dobesilate dispersible tablets in the treatment of diabetic nephropathy in phase IV, which can improve the renal function indices with high safety and without notable influence on blood glucose and lipid.
