Influence and Curative Effect of Bifidobacterium Tetravaccine Tablets on Serum Substance P and Neu-ropeptide Y Levels in Patients with Irritable Bowel Syndrome
- VernacularTitle:双歧杆菌四联活菌片对肠易激综合征患者血清 P物质和神经肽Y水平的影响及疗效观察
- Author:
Wenwei YANG
;
Zhenhong PAN
- Publication Type:Journal Article
- Keywords:
Irritable bowel syndrome;
Bifidobacterium tetravaccine tablets;
Substance P;
Neuropeptide Y
- From:
China Pharmacist
2015;(5):794-796
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the influence and curative effect of bifidobacterium tetravaccine tablets on serum substance P ( SP) and neuropeptide Y ( NPY) levels in the patients with irritable bowel syndrome ( IBS) . Methods: Totally 84 cases of patients with IBS were selected and divided into the observation group and the control group at random. The patients in the two groups were both given the medical treatment, such as diet adjustment, malntenance of water and electrolyte acid-base balance, administration of gastro-intestinal antispasmodic and antidiarrheal agents. The patients in the observation group were additionally given 0. 15g bifidobacterium tetravaccine tablets per time, three times a day for 8 weeks. The changes of serum SP and NPY levels in the two groups before and after the treatment were observed, and the clinical curative effect and adverse drug reaction ( ADR) were compared. Results:After the 8-week medical treatment, the serum SP level in the two groups was obviously declined than that before the treatment, while the NPY lev-el was obviously ralsed than that before the treatment (P<0. 05 or P<0. 01), and the declining or increase in the observation group was much higher than that in the control group (P <0.05). Meanwhile, the total clinical efficiency in the observation group was 95. 24%, which was much higher than that in the control group (78. 57%, P<0. 05). After comparing the occurrence of ADR be-tween the two groups, no statistical differences were appeared (P>0. 05). Conclusion:Bifidobacterium tetravaccine tablets show reli-able curative effect on IBS with high security, and the curative effect has close relationship with inhibiting the release of SP, enhancing the release of NPY, adjusting the excitement of braln gut axis and inhibiting the imbalance of braln gut petide in the patients with IBS.
