Study of Simulation Application of Simulink Pharmacokinetic Compartment Model
- VernacularTitle:Simulink药动学房室模型仿真应用的研究
- Author:
Wei CHEN
;
Yu WANG
;
Xiaofei FEI
;
Langui XIE
;
Guohui LI
- Publication Type:Journal Article
- Keywords:
Pharmacokinetics;
Two-compartment model;
Dynamic simulation
- From:
China Pharmacist
2015;(5):736-740
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To dynamically describe the drug concentration change in different time in vivo to understand the in vivo be-havior patterns and rules of drugs, provide reference for performing individual treatment and avoiding adverse drug reactions and lay foundation for dynamic description of physiological pharmacokinetic model. Methods:A two-compartment model was established using Simulink dynamic simulation and used in curve fitting and parameter estimation. The results from the model were compared with those from 3P97 software. Results:There was no significant difference between the results from the dynamic model and those from 3P97 soft-ware. Conclusion:The dynamic model can be used to dynamically simulate two-compartment model for oral administration. The re-sults from the dynamic simulation are more direct, and can correct the fitting error in 3P97 software.
