Preparation Technology of Buccal Tablets Containing Old Tea Leaf Extract
- VernacularTitle:老叶茶叶含片制备工艺研究
- Author:
Yuming LIU
;
Xianrong SHEN
;
Dengyong HOU
;
Wei CHEN
;
Qiong LIU
;
Ying HE
;
Kexian LI
;
Dingwen JIANG
;
Qingrong WANG
;
Qun LUO
- Publication Type:Journal Article
- Keywords:
Old tea buccal tablets;
Disintegration time;
Orthogonal design
- From:
China Pharmacist
2015;(5):747-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare old tea buccal tablets using wet granulation method and optimize the preparation technology. Methods:The amount of each adjuvant was studied by single factor experiments, and the formula of the buccal tablets was optimized by the orthogonal experiments using taste and disintegration time as indices. Results:The optimal formula was composed of old tea ex-tract 30 g,mannitol 60g,PEG6000 20 g,aspartame 10 g,citric acid 10 g and menthol crystal 1 g. All the tested indices including ap-pearance, hardness and disintegration time met the requirements described in Chinese pharmacopeia. Conclusion: The preparation technology is reasonable and feasible for the industrial production.
