Influence on Immune Function in Pationts in Postoperative Colorectal Carcinoma by the Treatment of Calf Spleen Extractive Injection Combined with Chemotherapy in Postoperative Colorectal Carcinoma
- VernacularTitle:小牛脾提取物注射液辅助化疗对结直肠癌术后患者免疫功能影响
- Author:
Xiaohua ZHOU
;
Haining CUI
- Publication Type:Journal Article
- Keywords:
Calf spleen extractive injection;
FOLFOX 4 regimen;
Colorectal carcinom;
Immune function
- From:
China Pharmacist
2015;(5):809-811
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the infuence of calf spleen extractive injection combined with chemotherapy on immune function of the patients after colorectal carcinoma. Methods:Totally 128 cases of postoperative colorectal carcinoma patients were randomly di-vided into two groups with 64 ones in each. The control group only received FOLFOX 4 regimen, while the study group received calf spleen extractive injection additionally from the first day to the tenth day, 10ml, ivd, and 14-day was one cycle. After 4 weeks, im-mune function, peripheral blood leukocytes ( WBC) , hemoglobin ( Hb) and platelet ( Plt) in the two groups were compared, and the adverse reactions were evaluated as well. Results: After the treatment, CD3 +, CD4 +, CD8 + and CD4/CD8 were increased in the study groups, and those in the study group were much higher than those in the control group (P<0. 05). After the treatment, there were no significant changes in WBC, Plt and Hb in the two groups (P>0. 05), while WBC and Plt in the study group were higher than those in the control group (P<0. 05). The incidence of adverse reactions in the study group was lower than that in the control group (P<0. 05). Conclusion:Calf spleen extractive injection combined with chemotherapy not only can increase the immune func-tion, but also alleviate myelosuppression and gastrointestinal toxicity in the treatment of postoperative colorectal carcinoma patients.
