The study of diffusion tensor imaging and cognitive function in patients with asymptomatic mild traumat-ic brain injury
- VernacularTitle:轻度脑外伤患者弥散张量成像与认知功能
- Author:
Maokun LI
;
Tao YANG
;
Lan ZHANG
;
Xiufeng XU
;
Mingqing XIANG
;
Hongyan JIANG
;
Hua WANG
- Publication Type:Journal Article
- Keywords:
Mild traumatic brain injury(mTBI);
Cognitive function P300;
Diffusion tensor imaging(DTI)
- From:
Chinese Journal of Nervous and Mental Diseases
2015;(4):229-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the features of white matter in DTI in patients with asymptomatic mild traumat?ic brain injury(mTBI)and their correlation with the cognitive features. Methods The DTI data and cognitive function data were obtained from 36 mTBI patients and 36 health controls. The fractional anisotropy (FA) pictures were ana?lyzed by voxel-based analysis. The FA value differences of the two groups were analyzed by using t test. The values of FA were extracted from the abnormal regions of mTBI patients. Correlation analyses were performed on the association of extracted FA value with P300 latency,P300 amplitude,the scores of Montreal Cognitive Assessment (MoCA) Scale, Hamilton Depression Scale, Hamilton Anxiey Scale,age and education(P>0.05). Results Compared with controls, mTBI patients had significant reduction of FA in the right medial frontal gyrus, bilateral postcentral gyrus, left precune?us, right posterior cingutate and right superior temporal gyrus(P<0.01,FDR correction). There were no significant correlations between extracted FA value and all clinical characteristics in mTBI patients. Conclusions Patients with mTBI have white matter microstructural damage and cognitive impairment.
