Relative Bioavailability of Sirolimus Dropping Pills in Rats
- VernacularTitle:西罗莫司滴丸在大鼠体内相对生物利用度研究
- Author:
Minghua ZOU
;
Shaoting LI
;
Xianxi GUO
- Publication Type:Journal Article
- Keywords:
Sirolimus;
Dropping pills;
Bioavailability;
Rats
- From:
China Pharmacist
2015;(6):919-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relative bioavailability of sirolimus ( SRL) dropping pills in rats. Methods:PEG6000 as the base, SRL dropping pills were prepared using solvent-melting method. The SRL marketed tablets as the reference preparation and rats as the animals, the relative bioavailability of SRL dropping pills was studied to obtain the pharmaceutical parameters and bioequiavail-ability. Results:Compared with that of the reference preparation, tmax of SRL dropping pills was the same (1 h). There was no signifi-cant difference in Cmax between the dropping pills and the tablets (P>0. 05). AUC0-24 of the dropping pills was notably higher than that of the marketed tablets (P<0. 05) with the bioequiavailability of 121. 98%. Conclusion:SRL dropping pills with promising bioavail-ability are valuable to be studied further.
