Protection against Myocardial Ischemia/Reperfusion Injury in Rats by Pretreatment with Paeoniflorin
- VernacularTitle:芍药苷预处理对大鼠心肌缺血再灌注损伤的保护作用
- Author:
Wenxia LIU
;
Junlian SHU
;
Li XU
;
Junping CAO
;
Yi MA
- Publication Type:Journal Article
- Keywords:
Paeoniflorin;
Myocardial ischemia/reperfusion injury;
SOD;
MDA
- From:
China Pharmacist
2015;(6):926-928
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protective effects of paeoniflorin on myocardial ischemia/reperfusion ( MI/R) injury in rats. Methods:The rat model of MI/R injury was prepared by coronary artery ligation for 30 min followed by 2-hour reperfusion. Then the rats were randomly divided into 5 groups:sham group, model group, paeoniflorin group respectively at high, medium and low dose (20, 10 and 5 mg·kg-1, n=10). Paeoniflorin was respectively injected via tail vein 1 h before the operation and at the beginning of the reperfusion. The CK, LDH and SOD activities and MDA contents in serum of rats were examined, and the area of myocardial in-farction was also calculated after the reperfusion. Results:Paeoniflorin (20 and 10 mg·kg-1 ) could significantly reduce the area of myocardial infarction when compared with the model group (P<0. 05). Paeoniflorin could obviously inhibit the CK and LDH activities (P<0. 05 or P<0. 01) and enhance the SOD activity (P<0. 01) in serum of MI/R rats. The MDA content in paeoniflorin groups at high and medium dose was significantly lower than that in the model group (P<0. 05). Conclusion:Paeoniflorin pretreatment shows effectiveness against MI/R injury, which may be associated with the inhibition of lipid peroxidation.
