Study on Promotion Effect of Recombinant Human Acidic Fibroblast Growth Factor on Wound Healing in Children by Multicenter Randomized Controlled Trials
- VernacularTitle:重组人酸性成纤维细胞生长因子促进儿童创面愈合的多中心、开放性随机对照试验
- Author:
Yuchang LIU
;
Jianning LIU
;
Yazhou LI
- Publication Type:Journal Article
- Keywords:
Recombinant human acidic fibroblast growth factor;
Children;
Wound healing
- From:
China Pharmacist
2015;(1):77-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the promotion effect of recombinant human acidic fibroblast growth factor ( rh-aFGF) on wound healing in children with surgery or accident injury. Methods: Totally 206 cases of injured children were randomly divided into two groups, the treatment group was given rh-aFGF, and the control group was treated with basic fibroblast growth factor (bFGF). The ob-servation of wound healing, infection and fat liquefaction in the children was recorded in 7 days,and the modification of scar, pigmenta-tion and adverse reactions were observed in 6 months after the treatment. Results:After the 7-day treatment by rh-aFGF and bFGF, the healing rate respectively was 88. 4% and 74. 2%, and the residual wound area was (2. 2 ± 1. 1) cm2 and (3. 9 ± 2. 4) cm2,respec-tively. Six months after the treatment, the scar incidence rate of the treatment group and the control group was 27. 2% and 67. 5%, and the incidence of pigmentation was 30. 1% and 69. 9%, respectively. Conclusion:Rh-aFGF is more effective than bFGF in pro-moting wound healing in children with surgery or accident injury. It can effectively promote wound healing, shorten the healing time, and diminish the area of scar and pigmentation.
