Rapid Detection of Ephedrine in Biyan Sprays with Fourier Transmittance Near-infrared Spectroscopy
- VernacularTitle:傅里叶近红外透射光谱法快速检测鼻炎喷剂中盐酸麻黄碱的含量
- Author:
Guanxin LV
;
Jifen HE
- Publication Type:Journal Article
- Keywords:
Fourier transmittance near-infrared ( FT-NIR) spectroscopy;
Transmission spectra;
Biyan sprays;
Ephedrine hydro-chloride
- From:
China Pharmacist
2015;(1):156-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a rapid analysis method for determining the content of ephedrine in Biyan sprays. Methods:The FT-NIR spectra of the samples were collected by near-infrared liquid transmission spectroscopy. Using the HPLC analysis values as the reference, a quantitative analysis model for ephedrine was established with partial least square ( PLS) , the first derivative and Nor-ris smooth was used in the spectra pretreatment, and 6 136. 38-5 364. 99 cm-1 and 7 038. 90-6 969. 48 cm-1 were selected as the fre-quency ranges. Results:R2 and RMSEC of the calibration set was 0. 992 6 and 1. 20, respectively. R2 and RMSEP of the vallidation set was 0. 993 5 and 1. 28, respectively. R2 and RMSEP of the cross validation set was 0. 986 9 and 1. 60, respectively. Conclusion:The method is rapid and non-desturctive, and can be applied in the rapid assessment and online examination of the quality of Biyan sprays.
