Study on General Pharmacology of Sansheng Jindan Capsules
- VernacularTitle:三升金丹胶囊的一般药理实验
- Author:
Fengjiao HUANG
;
Cong PANG
;
Xiaolin HUI
;
Jihong LI
- Publication Type:Journal Article
- Keywords:
Sansheng Jindan capsules;
General pharmacology;
Central nervous system;
Cardiovascular system;
Respiratory system
- From:
China Pharmacist
2015;(1):164-166
- CountryChina
- Language:Chinese
-
Abstract:
90,180 and 360 mg·kg-1 on general central nervous system (CNS) of mice was investigated by general behavior observation, nembu-tal subthreshold hypnosis experiment, spontaneous activity test and rotary rod test. The changes in blood pressure, heart rate, electro-cardiogram, breathing flow and frequency in anaesthetic Bealge dogs were observed to evaluate the effects of the capsules respectively at the low, medium and high dosage of 16,32 and 64 mg·kg-1 on cardiovascular and respiratory systems. Results:The general behavior of mice was normal after the administration of Sansheng Jindan capsules. The capsules showed no synergetic hypnotic effect on nembu-tal, and had no influence on the spontaneous activity and body coordination ability of mice (P>0. 05). The blood pressure, ECG and respiratory index of anaesthetic Bealge dogs were also normal after the administration of the capsules (P>0. 05). Conclusion:There are no significant effects of Sansheng Jindan capsules at the experimental dosages on central nervous system of mice and respiratory and cardiovascular systems of Beagle dogs.
