Preparation and Release Behavior in vitro of Memantine Hydrochloride Sustained-release Pellets
- VernacularTitle:盐酸美金刚缓释微丸的制备及体外释放度考察
- Author:
Qiongyan GU
;
Meiyuan WU
- Publication Type:Journal Article
- Keywords:
Memantine hydrochloride;
Sustained-release pellets;
Polyacrylic acid resin;
Zero-order kinetics model
- From:
China Pharmacist
2015;(2):233-237
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare sustained-release pellets of memantine hydrochloride and investigate the in vitro drug release be-havior. Methods:The drug-loaded pellets were prepared by a fluid bed coating technology, the sustained-release pellets were prepared with Eudragit RL 30D and Eudragit RS 30D as the coating materials, and in vitro drug release behavior of the sustained-release pellets was studied. Results:The in vitro drug release was steady and complete in 24h, which fit a zero-order kinetics model. Conclusion:The memantine hydrochloride sustained-release pellets has the sustained-release property.
