Helicobacter pylori Eradication Rate in Patients with Diabetes.
10.7704/kjhugr.2017.17.2.83
- Author:
Jiyeon YOO
1
;
Yeong Ji YU
;
Gumin CHO
;
Hongkwon OH
;
Seung Hyun OH
;
Tae Ho KIM
;
Jung Hwan OH
Author Information
1. Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. ojh@catholic.ac.kr, kimtaeho@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
Helicobacter pylori;
Prevalence;
Retrospective studies
- MeSH:
Biopsy;
Breath Tests;
Diabetes Mellitus;
Helicobacter pylori*;
Helicobacter*;
Humans;
Medical Records;
Peptic Ulcer;
Prevalence;
Proton Pumps;
Retrospective Studies;
Urease
- From:The Korean Journal of Helicobacter and Upper Gastrointestinal Research
2017;17(2):83-87
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The prevalence of diabetes mellitus is increasing. Little is known about the difference in Helicobacter pylori eradication rates between diabetic patients and non-diabetics. The aim of this study was to compare the eradication rate between diabetic and non-diabetic patients. MATERIALS AND METHODS: The medical records of patients who received a proton pump inhibitor (PPI)-based eradication therapy between 2012 and 2015 were retrospectively reviewed. All the patients underwent endoscopic biopsy to confirm H. pylori infection. Successful eradication was confirmed by using the ¹³C-urea breath test, biopsy, or rapid urease test, which was performed at least 4 weeks after the end of eradication therapy. RESULTS: A total of 1,402 patients were included. The eradication rate was 74.3% (1,041/1,402; 95% CI, 72.0~76.5%). Excluding 151 patients who were confirmed to have no diabetes, 182 diabetic and 1,069 non-diabetic patients were compared. No significant difference (P=0.667) in eradication rate with PPI-amoxicillin-clarithromycin therapy was found between the diabetic (75.8%, 138/182; 95% CI, 69.6~82.0%) and non-diabetic groups (74.0%, 791/1,069; 95% CI, 71.4~76.6%). Peptic ulcer was much more common in the diabetic group than in the non-diabetic group (67.0% vs. 57.9%, P=0.038). CONCLUSIONS: The H. pylori eradication rate with PPI-based triple therapy in the diabetic patients was probably not different from that in non-diabetic patients.
