Optimization of Alcohol Extraction Process of Yiqigutuo Granules by Orthogonal Test
- VernacularTitle:正交试验优选益气固脱颗粒醇提工艺研究
- Author:
Xian SUN
;
Xuanzhong TAN
;
Yongying LANG
- Publication Type:Journal Article
- Keywords:
Astragaloside;
Ferulic acid;
Alcohol extraction process;
Orthogonal test
- From:
China Pharmacist
2015;(3):410-413
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the alcohol extraction process of Yiqigutuo granules. Methods: Using the L9 (34 ) orthogonal design method, the active ingredients astragaloside and ferulic acid in the formula were quantitatively analyzed by HPLC. The concen-tration and amount of ethanol, extraction times and extraction duration and the other parameters affecting the extraction volume were ex-amined. Results:Analysis of variance showed that the ethanol concentration and extraction times had significant influence on the ex-tract content and the extraction of ferulic acid. The best alcohol extraction process was as follows:70% ethanol of 10-fold volume, ex-tracting 3 times with 1. 5h for each time. Conclusion:The process is stable, and suitable for the industrial production.
