Effect of Ulinastatin on Liver and Kidney Function in Patients with Hemorrhagic Shock
- VernacularTitle:乌司他丁对失血性休克患者肝肾功能的影响
- Author:
Li ZHOU
;
Xuguang LI
;
Xiankao LIN
- Publication Type:Journal Article
- Keywords:
Trauma;
Hemorrhagic shock;
Ulinastatin;
Liver and kidney function
- From:
China Pharmacist
2015;(3):424-426
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of ulinastatin on liver and kidney function in the patients with traumatic hemorrhag-ic shock. Methods:Totally 110 patients with traumatic hemorrhagic shock were divided into the control group (n=55) and the obser-vation group (n=55) according to the random number table. The control group received the conventional anti-shock treatment, and the observation group received ulinastatin with intravenous injection by syringe pump additonally. The changes of heart rate, urine vol-ume, liver function, renal function and inflammatory cytokine levels in the two groups were observed before and after the operation. Results:The heart rate at the 3rd h and 6th h after the operation in the observation group was significantly lower than that before the treatment , and urine volume was aslo significantly more than that before the treatment. The postoperative AST, ALT and LDH at the 3rd h and 6th h in the observation group were significantly lower than those in the control group at the same period, and the difference was significant (P<0. 05). The postoperative BUN, SCr andβ2-MG on the 1st day in the observation group were significantly higher than those before the surgery, and the difference was significant (P<0. 05);the postoperative BUN, SCr andβ2-MG on the 3rd day in the observation group were significantly different from those in the control group (P<0. 05). The postoperative IL-1β level on the 1st day in the observation group was significantly higher than that before the surgery (P<0. 05);the serum IL-1βlevel on the 3rd day in the observation group showed no statistically significant difference from that before the surgery (P>0. 05);the IL-6 levels on the 1st and 3rd day in the observation group were significantly higher than those before the surgery, however, lower than those in the control group with significant differences (P<0. 05). Conclusion: Ulinastatin has protective effect on liver and kidney function in the pa-tients with traumatic hemorrhagic shock, and can improve heart rate and urine output of the patients.
