Preparation and Dissolution of Jieheling Dispersible Tablets
- VernacularTitle:结核灵分散片的制备及其溶出度测定
- Author:
Hongai WANG
;
Jiwen XU
;
Man LI
- Publication Type:Journal Article
- Keywords:
Jieheling dispersible tablets;
Dissolution;
Fischeriana B
- From:
China Pharmacist
2015;(3):517-519
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare Jieheling dispersible tablets and establish the dissolution determination method. Methods:The dissolution of fischeriana B in the tablets was determined by HPLC. The column was Kromasil C18(250 mm ×4.6 mm,5μm)with ace-tonitrile-water (40∶60) as the mobile phase at a flow rate of 1. 0 ml·min-1 . The detection wavelength was at 290nm. The column temperature was 30℃ and the sample size was 100 μl. Results: The linear range of fischeriana B was 0. 005-0. 057 μg ( r =0. 999 6). The average recovery was between 95% and 105%. Phosphate solution with pH of 6. 8 was used as the dissolution medi-um. Conclusion:The method is simple, accurate and specific, and can be used in the quality control of Jieheling dispersible tablets.
