JAK/STAT pathway and its role in acute leukemia
10.3760/cma.j.issn.1673-422X.2014.06.018
- VernacularTitle:JAK/STAT信号通路与急性白血病
- Author:
Yan ZHUANG
;
Ligen LIU
- Publication Type:Journal Article
- Keywords:
Acute leukemia;
Therapy;
JAK/STAT pathway
- From:
Journal of International Oncology
2014;41(6):460-463
- CountryChina
- Language:Chinese
-
Abstract:
JAK/STAT is a central signaling pathway activated by cytokines binding with their respective receptors which can regulate cell proliferation,differentiation and apoptosis.Recent studies have suggested that abnormal signaling pathway with gene mutation and dysregulation plays an important role in the pathogenesis and progression of acute leukemia.The investigation of this pathway may provide novel target for therapies of acute leukemia.
