Research Advances in Mechanism of Bioactive Tanshinones in Salviae Miltiorrhiae Regulating Angiogenesis
- VernacularTitle:丹参多种活性成分调节血管新生机制的研究概述
- Author:
Qin ZHUANG
;
Wei MAO
- Publication Type:Journal Article
- Keywords:
Salviae Miltiorrhiae;
angiogenesis;
pro-angiogenic factors;
matrix metal oproteinase;
Hypoxia inducing factor 1 alpha;
Salvianolic acid B;
Tanshinone IIA;
dual regulation
- From:
Journal of Zhejiang Chinese Medical University
2014;(4):506-510
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To explore the mechanism of bioactive tanshinones in Salviae Miltiorrhiae regulating angiogenesis and lay the foundation for the prevention and treatment of cancer, atherosclerosis, ischemic heart disease and other angiogenesis-related diseases. [Method]Based on angiogenesis mechanisms, infer to recent 10 years of articles from home and abroad, analyze and summarize the angiogenesis regulatory mechanisms of various bioactive ingredients in Danshen on endothelial cells, in vitro tumour cells and in vivo xenograft tumor. [Result] Among various bioactive ingredients of Salvia, Salvianolic acid B, Tanshinone IIA, Cryptotanshinone, Dihydrotanshinone I can promote or inhibit angiogenesis. Furthermore, Salvianolic acid B and Tanshinone IIA are considered to be the most important bioactive ingredients in Danshen and exhibit a dual angiogenic regulating activity through regulating various approaches, such as pro-angiogenic factors, MMPs, HIF-1α, the PI3K/AKT/eNOS signal pathway and so on. [Conclusion]Various bioactive ingredients of Salvia can serve as a regulator of angiogenesis, and it may provide new ideas for the prevention of angiogenesis-related diseases.
