IL-21 level in Chinese HIV infected individuals and its dynamics undergoing HAART

VernacularTitle:中国HIV感染者的IL-21水平及其在高效抗反转录病毒治疗中的动态变化
Author: Liwen ZHENG ; Mamadou DIALLO ; Xia CHEN ; Yuhuang ZHENG ; Yan HE ; Huaying ZHOU ; Zi CHEN ; Yan LUO
Publication Type:Journal Article
Keywords: human immunodeficiency virus; highly active antiretroviral therapy; interleukin-21; CD4 cell; CD8 cell; HIV RNA
From: Journal of Central South University(Medical Sciences) 2011;36(11):1059-1064
CountryChina
Language:Chinese
Abstract: To investigate the dynamics of interleukin-21 (IL-21) cytokine in the Chinese HIV patients undergoing highly active antiretroviral therapy (HAAPT).Methods A total of 25 adults with chronic HIV infections,responding to combined highly active antiretroviral therapy (HAART) guideline criteria were enrolled for a 1-year follow-up.After signing an informed consent,20 mL blood was collected from each patient at the base line,6 month and 12 month,respectively.CD4 and CD8 cell count was quantified by flux cytometry,serum HIV RNA quantified by real time PCR and IL-21 concentrations by ELISA.Results IL-21 levels increased gradually during the follow-up but did not reach the healthy levels.IL-21 correlated positively with the CD4 cells but not with CD8 T cells.HIV RNA correlated negatively with CD4 cell count but did not show any relationship with the CD8 cells.Conclusion IL-21 has potential role in the immunopathogenesis of HIV,and might be an important factor in immune construction during HAART.