Multidrug resistance-associated protein 1( MRP1/ABCC1 ) polymorphism: from discovery to clinical application
10.3969/j.issn.1672-7347.2011.10.002
- VernacularTitle:MRP1/ABCC1基因多态性:从发现到临床应用
- Author:
Jiye YIN
;
Jianting ZHANG
- Publication Type:Journal Article
- Keywords:
multidrug resistance-associated protein 1;
ABCC1;
single nucleotide polymorphism;
drug resistance;
prognosis;
disease susceptibility
- From:
Journal of Central South University(Medical Sciences)
2011;36(10):927-938
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance-associated protein 1 (MRP1/ABCC1) is the first identified member of ABCC subfamily which belongs to ATP-binding cassette (ABC) transporter superfamily.It is ubiquitously expressed in almost all human tissues and transports a wide spectrum of substrates including drugs,heavy metal anions,toxicants,and conjugates of glutathione,glucuronide and sulfate.With the advance of sequence technology,many MRP1/ABCC1 polymorphisms have been identified.Accumulating evidences show that some polymorphisms are significantly associated with drug resistance and disease susceptibility.In vitro reconstitution studies have also unveiled the mechanism for some polymorphisms.In this review,we present recent advances in understanding the role and mechanism of MRP1/ABCC1 polymorphisms in drug resistance,toxicity,disease susceptibility and severity,prognosis prediction,and methods to select and predict functional polymorphisms.
