Genetic predictors of antipsychotic-induced weight gain: a case-matched multi-gene study
10.3969/j.issn.1672-7347.2011.08.003
- VernacularTitle:抗精神病药物所致体质量增加的遗传易感基因
- Author:
Renrong WU
;
Jingping ZHAO
;
Ping SHAO
;
Jianjun OU
;
Maihui CHANG
- Publication Type:Journal Article
- Keywords:
gene;
antipsychotic;
schizophrenia;
weight gain;
HTR2C;
leptin;
adiponectin
- From:
Journal of Central South University(Medical Sciences)
2011;36(8):720-723
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine associations between weight gain induced by antipsychotic and the polymorphisms of HTR2C gene -759C/T and -697G/C,histamine-1 receptor gene,leptine gene -2548G/A,and adiponectin gene +276G/T and +45T/G.Methods In the casematched study,85 patients who gained more than 7％ of their pre-drug body weight served as the study group and another 85 patients who gained less than 7％ of their pre-drug body weight served as the control group.The ligation diction reaction technique was used to analyze the frequencies of the -759C/T and -697G/C polymorphism of the HTR2C gene,-2548A/G polymorphism of leptin gene,+ 276G/T and + 45T/G polymorphism of adiponectin gene and glu349asp polymorphism of H1 receptor gene.Results The presence of the -759C allele,-697G allele,-2548A allele and + 276G allele was significantly higher in the study group than that in the control group (P ＜ 0.05 ).Conclusion The -759C/T and -697G/C polymorphisms of the promoter region of 5HT2C receptor gene,-2548A/G polymorphisms of leptin gene and + 276G/T polymorphisms of adiponectin gene may be associated with the antipsychotic induced weight gain.The glu349asp polymorphisms of histamine-1 receptor gene is not associated with antipsychotic induced weight gain.
