Microstructural disruption of white matter in heroin addicts revealed by diffusion tensor imaging: a controlled study
10.3969/j.issn.1672-7347.2011.08.005
- VernacularTitle:海洛因成瘾者脑白质微结构受损的弥散张量成像研究
- Author:
Xuyi WANG
;
Xuhui ZHOU
;
Yanhui LIAO
;
Jinsong TANG
;
Tieqiao LIU
;
Wei HAO
- Publication Type:Journal Article
- Keywords:
diffusion tensor imaging;
white matter;
fractional anisotropy;
heroin addiction
- From:
Journal of Central South University(Medical Sciences)
2011;36(8):728-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine white matter integrity in heroin-dependent patients and matched normal controls with diffusion tensor imaging (DTI).Methods The fractional anisotropy was compared between 15 heroin-dependent patients and 15 controls.Results We found the fractional anisotropy was significantly decreased in specific brain regions of the heroin-dependent patients (P ＜ 0.001 uncorrected),including the frontal gyrus,the parietal lobule,the insula,and the corpus callosum.Conclusion The presence of microstructural abnormality is found in the white matter of several brain regions of heroin-dependent patients.
