Brain function of heroin addicts after withdrawal
10.3969/j.issn.1672-7347.2011.08.006
- VernacularTitle:海洛因成瘾者停止吸毒后的脑功能变化
- Author:
Xuyi WANG
;
Xuhui ZHOU
;
Yanhui LIAO
;
Jinsong TANG
;
Tieqiao LIU
;
Wei HAO
- Publication Type:Journal Article
- Keywords:
heroin;
abstinence;
functional magnetic resonance imaging;
blood oxygen level dependent
- From:
Journal of Central South University(Medical Sciences)
2011;36(8):733-738
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore what brain regions are modulated by heroin addiction and withdrawal.MethodsWe used functional magnetic resonance imaging to investigate the brain function in 15 heroin-dependent patients 3 days (acute) and 1 month (protracted) after heroin abstinence.Sixteen normal controls were included.Results The blood oxygen level-dependent signal in the orbitofrontal cortex of the brain of heroin-dependent patients was significantly elevated 3 days after the withdrawal.Hyperfunction of the orbitofrontal cortex declined 1 month after the withdrawal.Conclusion Heroin-dependent subjects at both 3 days and 1 month abstinence have persistent abnormalities in the brain function.Although some tangible beneficial effects are noted following 1month of detoxification,possible permanent damage to the brain caused by heroin use is suggested.
