Influence of nucleotides metabolism on insulin secretion:an analysis of the primary effect factors
- VernacularTitle:核苷酸代谢对胰岛素分泌影响的主要相关因素分析
- Author:
Changqing XIAO
;
Ning XIA
;
Huanzhong SHI
- Publication Type:Journal Article
- Keywords:
Insulin secretionK+ATP channelNucleotide metabolism
- From:
Chinese Journal of Diabetes
2000;8(4):224-226
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo determine the primary control factors of nucleotides metabolisms on insulin secretion.MethodsNMRI mice isolated islets were used to investigate the amount of insulin secretion and the changes of ATP,ADP,GTP,GDP and UTP in islets when the activity of K+ATP channel was eliminated by diazoxide.ResultsThe above assays demonstrated that insulin secretion increased with the rise of glucose concentration.In the same time,ratio of ATP/ADP,GTP/GDP and level of UTP increased,too.All three indexes correlated with the insulin secretion very well respectively,but only ratio of ATP/ADP can control insulin secretion directly in common influence.ConclusionOur findings suggest that there is the second control site in islets when glucose induces insulin secretion and ATP/ADP ratio is only key factor in this mechanism.
