Correlation between high mobility group box-B1 and gastrointestinal tumors
10.3760/cma.j.issn.1673-422X.2011.06.020
- VernacularTitle:高迁移率族蛋白B-1与胃肠道肿瘤的相关性
- Author:
Jing ZHANG
;
Jinshui ZHU
- Publication Type:Journal Article
- Keywords:
HMGB1;
Gastrointestinal neoplasms
- From:
Journal of International Oncology
2011;38(6):459-462
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box-B1 (HMGB1)is a non histone DNA-binding protein and extracellular molecule related to damage.Normally it is located inside the cell and exerts a variety of biological effects. It has been demonstrated that the expression of HMGB1 presents in almost all gastrointestinal tumors and is closely correlated with the cell growth, proliferation, invasion and metastasis of gastrointestinal tumors. It has been discovered that HMGB1 inhibitor inhibits growth and metastasis of gastrointestinal tumors, which might become a new approach to the treatment of gastrointestinal tumors.
