Expressions of the gp80 and gp130 subunits of the IL- 6 receptor in the bone marrow of osteoporosis
- VernacularTitle:白细胞介素-6受体亚单位gp80和gp130在骨质疏松症中的基因表达
- Author:
Xiuzhen ZHANG
;
Jiang LUO
;
Hong CHEN
- Publication Type:Journal Article
- Keywords:
gene expression;
receptors,interleukin- 6;
osteoporosis
- From:
Chinese Journal of Tissue Engineering Research
2003;7(9):1374-1375
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the change of the expression of the gp80 and gp130 subunits of the IL- 6 receptor (IL- 6R)in the osteoporotic bone marrow, to explore the role of IL- 6 receptor system in the osteoporosis resulted from the loss of estrogen.Methods Twenty female 12- week old SD rats [weight (200± 20) g] were randomly divided into 2 groups: the osteoporosis model group (10 rats),the control group (10 rats).Respectively in the 0th ,12th week after ovariectomy to analyze the levels of gp80 and gp130.Results In the 0th,12th week after ovariectomy,the level of gp130 (pg/μ g total RNA): the control group's level had no significant change (80± 3 vs 82± 4,t=0.85,P >0.05), while the osteoporosis group's level became significant higher (80± 3 vs 290± 40,t=6.46,P< 0.01).In the 0th ,12th week after ovariectomy, the level of gp80(pg/μ g total RNA): the control group's level had no significant change (85.4± 2.7 vs 85.6± 2.8,t=0.35,P >0.05), while the osteoporosis group's level became significant higher (85.4± 2.7 vs 210± 40,t=6.32,P< 0.01).Conclusion There was a significant increase of the expressions of gp130 and gp80 in the bone marrow of osteoporotic rat.
