Diffusion tensor imaging study of white matter fiber in patients with schizophrenia episode in early adulthood
10.7683/xxyxyxb.2017.11.005
- VernacularTitle:成年早期起病精神分裂症患者脑白质弥散张量研究
- Author:
liang Ben LI
1
;
feng Yong YANG
;
xing Hong ZHANG
;
san Hai ZHANG
;
qiang Wen LI
;
Dai ZHANG
;
xian Lu LYU
Author Information
1. 新乡医学院第二附属医院精神科
- Keywords:
schizophrenia;
white matter;
diffusion tensor imaging;
fractional anisotropy;
mean diffusivity
- From:
Journal of Xinxiang Medical College
2017;34(11):974-977
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the structure changes of white matter of the patients with schizophrenia episode in early adulthood by diffusion tensor imaging(DTI) and in order to provide a structural neuroimaging basis for understanding the pathology of schizophrenia.Methods Twenty-six patients with schizophrenia episode in early adulthood in the Second Affiliated Hospital of Xinxiang Medical University from July 2012 to March 2014 were selected as study group and twenty-eight healthy subjects whose age,sex,education were matched with study group were selected as control group.All subjects received structural magnetic resonance imaging and DTI scans.The fractional anisotropy (FA) and the mean diffusivity (MD) of the white matter of the same encephalic region were compared between the two groups by voxel-based analyses.Results The FA values of the right anterior cingulate gyrusthe,genu of corpus callosum,the right limb of internal capsule,the bilateral external capsule,the bilateral posterior of coronal radiate,the right anterior coronal radiate of patients in the study group were significantly lower than those in the control group (P ＜ 0.05).The MD values of the bilateral limbs of internal capsule,the right cingulate gyrus,left superior longitudinal tract,corpus callosum and right anterior coronal radiate of patients in the study group were significantly higher than those in the control group (P ＜ 0.05).Conclusion Schizophrenia patients who episode in early adulthood exist widespread microstructural damage of white matter.These changes may be related to the pathological change of schizophrenia.
