High-affinity glutamate transporters and chronic pain

VernacularTitle:高亲和力谷氨酸转运体与慢性疼痛
Author: Hua ZHANG ^{1
,

2} ; 甘肃省骨关节疾病研究重点实验室 ; Shenghong WANG ; Qiqi XIE ; Wenzhou LI ; Weidong SHI ; Jinglin MA ; Jing WANG
Author Information

1. 兰州大学第二医院骨科
2. 甘肃省骨关节疾病研究重点实验室
Keywords: glutamate; high-affinity glutamate transporters; chronic pain
From: Journal of Central South University(Medical Sciences) 2017;42(9):1094-1099
CountryChina
Language:Chinese
Abstract: Glutamate serves as a major excitatory neurotransmitter in the mammalian central nervous system and is stored in synaptic deft by an uptake system that is dependent on the high-affinity glutamate transporters (ETTAs),which locate in the plasma membrane of glial cells and neurons.ETTAs can rapidly terminate the action of glutamate and maintain its normal physiological functions.If the content or function of glutamate transporters is abnormal,it can result in many physiological dysfunctions.Studies have demonstrated that high-affinity glutamate transporters play an important role in the development of chronic pain,which might be a new therapeutic target for the pain.