Mechanism of migration and release of high mobility group box-1
10.11817/j.issn.1672-7347.2017.09.019
- VernacularTitle:高迁移率族蛋白B1迁移及释放的机制
- Author:
Xin ZHAO
1
;
Ben L(U)
;
Erhua WANG
Author Information
1. 中南大学湘雅三医院血液科
- Keywords:
high mobility group box-1;
nucleus localization sequences;
post-translational modifications;
programmed cell death;
double-stranded RNA-dependent protein kinase
- From:
Journal of Central South University(Medical Sciences)
2017;42(9):1111-1115
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box-1 (HMGB1) is an evolutionarily conserved protein,which widely exists in mammals.HMGB 1 contains the nucleus localization sequences.Intracellular and extracellular HMGB1 shows different biological functions.Extracellular HMGB1 is closely related to sepsis,cancer,rheumatoid immune,atherosclerosis,ischemia-reperfusion injury and so on.The mobilization of HMGB 1 from the nucleus to the cytoplasm and subsequent release involves the processes of post-translation modification,active secretion and nuclear localization.
