Danzhi Xiaoyao capsule combined with leuprorelin acetate for treatment of central precocious puberty in children
10.7683/xxyxyxb.2017.12.015
- VernacularTitle:丹栀逍遥胶囊联合亮醋酸丙瑞林治疗儿童中枢性性早熟疗效观察
- Author:
min Chang ZHANG
1
Author Information
1. 信阳市中心医院儿科
- Keywords:
central precocious puberty;
Danzhi Xiaoyao capsule;
leuprolide acetate
- From:
Journal of Xinxiang Medical College
2017;34(12):1104-1106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of Danzhi Xiaoyao capsule combined with leuprolide acetate for treatment of central precocious puberty(CPP) in children.Methods One hundred and six female children with CPP in Xinyang Central Hospital from March 2015 to December 2016 were selected and divided into control group and observation group by random digits table,with 53 children in each group.The children in the control group were given leuprolide acetate subcutaneously;based on this,the children in the observation group were given Danzhi Xiaoyao capsule.After treatment,the ovarian volume,uterine volume,bone age index,sex hormone,height change,clinical efficacy and adverse reactions of children were compared between the two groups.Results Before treatment,there was no statistic difference in the ovarian volume,uterine volume and bone age index of children between the two groups (P ＞ 0.05);the ovarian volume,uterine volume and bone age index of children in the two groups after treatment were significantly lower than those before treatment (P ＜ 0.05);the ovarian volume,uterine volume and bone age index of children in the observation group were significantly lower than those in the control group (P ＜ 0.05).Before treatment,there was no statistic difference in the luteotropic hormone (LH),follicle-stimulating hormone (FSH) and estradiol(E2) levels of children between the two groups (P ＞ 0.05);the LH,FSH and E2 levels of children in the two groups after treatment were significantly lower than those before treatment (P ＜ 0.05);the LH,FSH and E2 levels of children in the observation group were significantly lower than those in the control group (P ＜ 0.05).The height growth speed of children in observation group [(4.52 + 0.83) cm · a-1] was significantly lower than that in control group [(7.35 ± 1.02) cm · a-1] (P ＜ 0.05).The total effective rate of children in observation group (92.45％) was significantly higher than that of control group (73.58％) (x2 =6.692,P ＜ 0.05).There was no adverse effects in the two groups during treatment.Conclusion Danzhi Xiaoyao capsule combined with leuprolide acetate for treatment of central precocious puberty in children has evident effect,less adverse reactions;it can effectively regulate the sex hormones levels of body,and delay the growth time.
