Correlation between 25-hydroxyvitamin D and autoimmune hepatitis
10.7683/xxyxyxb.2017.12.009
- VernacularTitle:25-OH维生素D与自身免疫性肝炎的相关性
- Author:
wei Wei LI
1
;
wen Xin SONG
Author Information
1. 新乡医学院第一附属医院感染科
- Keywords:
autoimmune hepatitis;
25-hydroxyvitamin D;
correlation
- From:Journal of Xinxiang Medical College
2017;34(12):1080-1084
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between autoimmune hepatitis (AIH) and 25-hydroxyvitamin D (25-OH VD) level.Methods A total of 150 patients with AIH in the First Affiliated Hospital of Xinxiang Medical University were selected as the observation group,and 70 healthy people with were selected as the control group.The fasting venous blood was taken from the subjects in the two groups.The level of serum 25-OH VD were detected by enzyme-linked immunosorbent assay.The clinical data of the subjects were collected and the factors influencing the serum 25-OH and VD level in AIH patients were analyzed.Results The rate of vitamin D deficiency in the observation group was significantly higher than that in the control group (84.67% vs 34.29%;x2 =56.28,P < 0.05).The level of 25-OH VD in the observation group was significantly lower than that in the control group before treatment (P < 0.05).The level of 25-OH VD in the patients with more than 60 years old was significantly lower than that in the patients with 30-49 and 50-59 years old in the observation group before treatment (P < 0.05).The level of 25-OH VD in the patients with 50-59 years old was significantly lower than that in the patients with 30-49 years old before treatment (P < 0.05).The level of 25-OH VD after treatment was significantly higher than that before treatment in the observation group (P < 0.05).The level of 25-OH VD after treatment was significantly higher than that before treatment in the patients with 30-49,50-59 and more than 60 years old (P < 0.05).The level of 25-OH VD in the patients with more than 60 years old was significantly lower than that in the patients with 30-49 and 50-59 years old in the observation group after treatment (P < 0.05).The level of 25-OH VD in the patients with 50-59 years old was significantly lower than that in the patients with 30-49 years old after treatment (P < 0.05).The age,course of disease,body mass index,and the levels of serum alanine transarninase (ALT),aspartate aminotransferase (AST),r-glutamyl transpeptidase (r-GT),immunoglobulin G (IgG),IgM in the patients with vitamin D deficiency were significantly higher than those in the patients without vitamin D deficiency in the observation group (P < 0.05);but the level of seralbumin in the patients with vitamin D deficiency was significantly lower than that in the patients without vitamin D deficiency (P < 0.05).There was no significant difference in the age and the levels of serum parathyroid hormone,total bilirubin,alkaline phosphatase between the patients with vitamin D deficiency and the patients without vitamin D deficiency (P < 0.05).The levels of serum AST,ALT and r-GT were the independent influencing factors for 25-OH VD (P < 0.05).Conclusion The level of serum 25-OH VD is lower in the patients with AIH,and ALT,AST and r-GT were important factors affecting serum 25-OH VD level in patients with AIH.