Curative effect analysis of Linggui Zhugan Decoction in the treatment of metabolic syndrome induced by antipsychotic drugs
10.7683/xxyxyxb.2017.12.010
- VernacularTitle:苓桂术甘汤治疗抗精神病药物所致代谢综合征疗效分析
- Author:
Hua OU-YANG
1
;
yuan Zhang WANG
;
mei Gui CUI
Author Information
1. 新乡医学院第二附属医院心身疾病二科
- Keywords:
metabolic syndrome;
Linggui Zhugan Decoction;
antipsychotic drugs
- From:
Journal of Xinxiang Medical College
2017;34(12):1085-1088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effectiveness and safety of Linggui Zhugan Decoction in the treatment of metabolic syndrome(MS) induced by antipsychotics.Methods Sixty MS patients were enrolled who also matched the diagnostic criteria for phlegm stagnation type.These 60 patients who were treated in the Second Affiliated Hospital of Xinxiang Medical University were randomly divided into the observation group and control group,each group included 30 patients.The patients in the observation group were given the treatment of Linggui Zhugan Decoction in addition to antipsychotic treatment,while the patients in the control group were only given antipsychotic treatment.After two weeks or four weeks of treatment,the levels of triglyceride (TG),high density lipoprotein (HDL),fasting plasma glucose,insulin,C-peptide and insulin resistance index (HOMA-IR) were compared between the two groups before and after treatment.Results After two weeks or four weeks treatment,the levels of TG,fasting plasma glucose,insulin,C-peptide and HOMA-IR significantly increased and that of HDL decreased significantly in the control group patients compared with those before treatment (P ＜ 0.05),while the results in the observation group were opposite (P ＜ 0.05).In the control group patients,the levels of insulin,HOMA-IR and C-peptide after four weeks treatment were significantly higher than those after two weeks treatment (P ＜ 0.05).However,in the observation group patients,the levels of insulin,HOMA-IR and C-peptide after four weeks treatment were significantly lower than those after two weeks treatment (P ＜ 0.05).Compared with the control group,after two weeks or four weeks treatment the levels of TG,fasting plasma glucose,insulin,C-peptide and HOMA-IR decreased significantly in the observation group patients and that of HDL increased significantly (P ＜ 0.05).The treatment emergent symptom scale score of the observation group was lower than that of the control group at the end of four weeks (P ＜ 0.05).Conclusion Linggui Zhugan Dcoction can improve MS caused by antipsychotics and has good safety.
