Effect of imipenem and cilastatin sodium in the treatment of severe pneumonia
10.7683/xxyxyxb.2017.12.022
- VernacularTitle:亚胺培南西司他丁钠治疗重症肺炎疗效观察
- Author:
Bo YIN
1
;
ying Yin ZHAO
Author Information
1. 南京医科大学附属无锡市人民医院呼吸科
- Keywords:
severe pneumonia;
imipenem and cilastatin sodium;
procalcitonin;
C-reactive protein;
cough score
- From:Journal of Xinxiang Medical College
2017;34(12):1128-1130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of imipenem and cilastatin sodium in the treatment of severe pneumonia.Methods Sixty patients with severe pneumonia were selected from May 2013 to August 2016 in Wuxi People's Hospital.The patients were divided into observation group and control group according to the treatment method,30 cases in each group.The patients in the control group were treated with cefoperazone and sulbactam injection,and the patients in the observation group were treated with imipenem and cilastatin sodium.The levels of serum procalcitonin (PCT) and C-reactive protein (CRP) were measured,and the cough score was performed in the two groups before and after treatment.The clinical effect was evaluated after treatment,and the adverse reactions of the patients were recorded in the two groups.Results There were no significant difference in the levels of serum PCT and CRP between the two groups before treatment (P ＞ 0.05).The levels of serum PCT and CRP after treatment were significantly lower than those before treatment in the two groups (P ＜ 0.05).The levels of serum PCT and CRP in the observation group were significantly lower than those in the control group after treatment (P ＜ 0.05).There was no significant difference in cough score between the two groups before treatment (P ＞ 0.05).The cough score after treatment was significantly lower than that before treatment in the two groups (P ＜ 0.05).The cough score in the observation group was significantly lower than that in the control group after treatment (P ＜ 0.05).The total effective rate in the observation group and the control group was 93.33％ (14/15) and 60.00％ (9/15) respectively,the total effective rate in the observation group was significantly higher than that in the control group (x2 =4.658,P ＜ 0.05).The incidence of adverse reactions in the two groups was 6.67％,there was no significant difference in the incidence of adverse reactions between the two groups (x2 =0.000,P ＞ 0.05).Conclusion Imipenem and cilastatin sodium can significantly reduce the inflammatory response and clinical symptoms in patients with severe pneumonia,and the curative effect is remarkable.
