Inhibitory effect of ethosuximide on sevoflurane-induced emergence delirium in neonatal rats
- VernacularTitle:乙琥胺对七氟醚诱发幼鼠躁动的抑制作用
- Author:
Wen WEN
1
;
Bo CAO
;
Fengyan SHEN
;
Xuan ZHAO
Author Information
1. 200092,上海交通大学医学院附属新华医院麻醉与重症医学科
- Keywords:
Sevoflurane;
Ethosuximide;
Frontal lobe;
EEG power spectrum;
Emergence delirium
- From:
The Journal of Clinical Anesthesiology
2017;33(11):1112-1114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibitory effect of ethosuximide,an antiepileptic drug,on sevoflurane-induced emergence delirium in neonatal rats.Methods Twelve SD rats (17-23 g) at postnatal day 9-11 were randomly divided into ethosuximide group (4 mg/100 μl,intraperitoneal injection,n=6) and saline group (100 μ1,intraperitoneal injection,n =6).Then the pups were treated with 1％ sevoflurane for 10 minutes and agitated behaviors was observed using PAHBs scoring method for every 2 minutes.Ten more pups were randomly divided into two groups as previously described.Then the pups were treated with 1％ sevoflurane for 10 minutes and EEG power spectrum of frontal lobe was monitored for every 2 minutes.Results Both PAHBs scores and EEG power spectrum at 2 min,4 min,6 min,8 min and 10 min were significantly decreased in ethosuximide group when comparing with saline group under 1％ sevoflurane inhalation (P ＜ 0.05).Conclusion Ethosuximide can decrease frontal lobe EEG power spectrum in sevoflurane-induced agitated rats and inhibit sevoflurane-induced emergence delirium in neonatal rats.
