The effect of single dose of brimonidine-purite 0.15％ on choroidal thickness in healthy volunteers
10.3980/j.issn.1672-5123.2017.11.03
- VernacularTitle:单剂量0.15％酒石酸溴莫尼定对正常个体脉络膜厚度的影响
- Author:
Demircan yman SULE
1
;
Gokce G(O)K(C)EN
;
Ata(s) MUSTAFA
;
Gülhan AHMET
;
Balkan BURHAN
;
Zararsiz GOKMEN
Author Information
1. 38010土耳其,开塞利,开塞利医疗研究医院,眼科
- Keywords:
brimonidine;
choroidal thickness;
enhanced depth imaging;
intraocular pressure;
optical coherence tomography
- From:
International Eye Science
2017;17(11):2000-2004
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To evaluate the potential posterior segment effects of topical application of brimonidine-purite 0.15％ through measurement of choroidal thickness (CT) in healthy eyes using enhanced depth imaging spectraldomain optical coherence tomography (EDI-SD-OCT).METHODS:Thirty-two eyes of 32 healthy subjects were included in this prospective,placebo controlled interventional clinical trial.They received one drop of topical preservative-free artificial tears as placebo for the first day and one drop of brimonidine-purite 0.15％ for the second day.Intraocular pressure,ocular perfusion pressure (OPP),and EDI-SD-OCT were performed at baseline,at 1,3 and 5h after the treatments.RESULTS:Compared to the measurements obtained at baseline,the CT measurements obtained after the topical application of brimonidine-purite 0.15％ significantly increased at the sub-fovea (P=0.001),at temporal 1500 μm to the fovea (P=0.003) and at nasal 1500 μm to the fovea (P=0.003).Choroidal thickness was unchanged in placebo group during the study (P ＞0.05).There was no significant reduction in the OPP in both groups (P ＞0.05).There were no adverse events during the study.CONCLUSIONS:Contrary to expectations,topical administration of brimonidine-purite 0.15％ resulted with thickening of sub-foveal,temporal and nasal CT.This might be related to altered auto-regulation mechanisms in choroidal vessels.
