Mechanisms for castration-resistance of prostate carcinoma
10.11817/j.issn.1672-7347.2017.10.015
- VernacularTitle:前列腺癌的去势抵抗机制
- Author:
Fangzhi CHEN
1
;
Xiaokun ZHAO
Author Information
1. 中南大学湘雅二医院泌尿外科
- Keywords:
prostate cancer;
castration-resistance;
androgen receptor reactivation;
tumor microenvironment
- From:
Journal of Central South University(Medical Sciences)
2017;42(10):1217-1221
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is the most prevalent male urogenital malignancy.The tumor cells are prone to castration-resistance after androgen deprivation therapy.Variation and reactivation of androgen receptor,and the change in the tumor microenvironment are the major pathological factors for development of castration-resistant prostate carcinoma (CRPC).Systematically analyzing and understanding the mechanisms for castration-resistance of prostate carcinoma will be significant for laying the basis for improvement of the strategies on precise treatment for CRPC.
